Daxx (death-associated protein, Daxx) was first reported to mediate the apoptotic signal from Fas to JNK in the cytoplasma resulting in enhanced Fas-mediated apoptosis and activation of Jun N-terminal Kinase (JNK) pathway tq. However, several lines of evidences also indicate that Daxx is mainly located in the nucleus and functions as an transcriptional regulator. Several proteins have been reported to interact with Daxx, including Fas, ASK1, DNA methyltransferase I, PML, ETS1, Pax3, Pax5, histone deacetylase, HSP27, the centromere-associated protein, CENP-C [2"6]. Tumorigenic mutant p53 Received date: Nov. 1, 2004; Accepted date: Jan. 17, 2005 Foundation item: This work was supported by a grant from the Education Committee of Hunan Province (No.02C391). *Author to whom correspondence should be addressed. Phone: (0086-734)-8282907; Fax: ((0086-734)-8282907; E-mail: yanpingwan@hobnail.com Biography: LIU An-yuan (1970-), male, master of medicine, assistant professor, Nanhua University, majors in molecular biology and tumor immunology. E-mail: liuanyuandkj@ hotmail.com can bind to Daxx and inhibit ASKl-mediated stress-inducible kinase pathways 17].
