Received date: Apr. 23, 2003; Accepted date: Sep. 18, 2003. Foundation item: This work was supported by grants from Ministry of Education of P.R. China (No. 2000--65). *Author to whom correspondence should be addressed. Phone: (0086-734)-8281308; Fax: (0086-734)-8280135. E-mail: dfliao@hotmail.com Biography: Wan Yah-ping(1965-), female, professor, master of medicine, Nanhua University, majors in microbiology and immunology. Phone/Fax: (0086-734)-8281386; E-mail: yanpingwan@hotmail.com Recent data suggest that human Daxx(hDaxx) is a naive transcriptional regulation protein ~2t. hDaxx interacts with promyelocytic leukemia protein(PML) and co-localize at the PML oncogenic domains (PODs), which depends on the presence of PML. hDaxx and PML are key proteins at PODs. Their co-localization at PODs is critical for formation and maintenance of spherical structure or the proper localization of all other PODs-associated proteins E3'41.
