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Folic Acid-Targeted MXene Nanoparticles for Doxorubicin Loaded Drug Delivery

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成果类型:
期刊论文
作者:
Zhen Liu;Lan Xie;Jia Yan;Pengfei Liu;Huixiang Wen;...
通讯作者:
Liu, Huijun(liuhuijun@usc.edu.cn)
作者机构:
[Zhen Liu; Lan Xie; Jia Yan; Huijun Liu] Department of Chemistry and Chemical Engineering, University of South China, Hunan, Hengyang
421001, China
[Pengfei Liu; Huixiang Wen] Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hunan, Hengyang
[Zhen Liu; Huijun Liu] 421001, China<&wdkj&>Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hunan, Hengyang
[Zhen Liu; Lan Xie; Jia Yan; Pengfei Liu; Huixiang Wen; Huijun Liu] 421001, China
语种:
英文
关键词:
MXenes, targeted drug carrier, folate receptors, nanoparticles, doxorubicin, pH-responsive mechanism, cancer therapy.
期刊:
Australian Journal of Chemistry
ISSN:
0004-9425
年:
2021
卷:
74
期:
12
页码:
847-855
机构署名:
本校为第一机构
院系归属:
化学化工学院
摘要:
MXenes are two-dimensional (2D) materials with a large specific surface area and abundant surface functional groups. A folate receptors-targeted drug carrier was constructed based on the rich surface functional groups and high biocompatibility of MXenes. This drug carrier possesses as high as 69.9 % drug-loading capability and as long as 48 h drug release time. Tumour targeting and a pH-responsive mechanism can make MXene nanoparticles quickly accumulate in tumour sites and slowly release loads. The results showed that DOX was released in a lar...

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