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Drug Discovery Targeting Post-Translational Modifications in Response to DNA Damages Induced by Space Radiation

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成果类型:
期刊论文
作者:
Xie, Dafei;Huang, Qi;Zhou, Pingkun
通讯作者:
Pingkun Zhou
作者机构:
[Huang, Qi; Xie, Dafei; Zhou, Pingkun] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol BKLRB, Taiping Rd 27th, Beijing 100850, Peoples R China.
[Huang, Qi; Zhou, Pingkun] Univ South China, Sch Publ Hlth, Dept Prevent Med, Changsheng West Rd 28th, Hengyang 421001, Peoples R China.
通讯机构:
[Pingkun Zhou] D
Department of Radiation Biology, Beijing Key Laboratory for Radiobiology (BKLRB), Beijing Institute of Radiation Medicine, Taiping Road 27th, Haidian District, Beijing 100850, China<&wdkj&>Department of Preventive Medicine, School of Public Health, University of South China, Changsheng West Road 28th, Zhengxiang District, Hengyang 421001, China<&wdkj&>Author to whom correspondence should be addressed.
语种:
英文
关键词:
radiation protection;space radiation;DSB;post-translational modification;drug target;drug discovery
期刊:
International Journal of Molecular Sciences
ISSN:
1422-0067
年:
2023
卷:
24
期:
8
页码:
7656-
基金类别:
Conceptualization, P.Z.; investigation, D.X. and Q.H.; writing—original draft preparation, D.X. and Q.H.; writing—review and editing, D.X. and P.Z.; visualization, D.X.; supervision, P.Z.; project administration, P.Z.; funding acquisition, D.X. and P.Z. All authors have read and agreed to the published version of the manuscript. This research was funded by Beijing Natural Science Foundation, grant number 7232107, the Young Elite Program, grant number AMMS-QNTB-2022-001 to D.X., and the National Natural Science Foundation of China (NSFC), grant number 32171238 to P.Z.
机构署名:
本校为其他机构
院系归属:
医学院
公共卫生学院
摘要:
DNA damage in astronauts induced by cosmic radiation poses a major barrier to human space exploration. Cellular responses and repair of the most lethal DNA double-strand breaks (DSBs) are crucial for genomic integrity and cell survival. Post-translational modifications (PTMs), including phosphorylation, ubiquitylation, and SUMOylation, are among the regulatory factors modulating a delicate balance and choice between predominant DSB repair pathways, such as non-homologous end joining (NHEJ) and homologous recombination (HR). In this review, we focused on the engagement of proteins in the DNA da...

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