Regulating the Heme Active Site by Covalent Modifications: Two Case Studies of Myoglobin

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成果类型：

期刊论文

作者：

Chen, Ze-Yuan;Yuan, Hong;Wang, Huamin;Sun, Li-Juan;Yu, Lu;...

通讯作者：

Lin, YW

作者机构：

[Wang, Huamin; Lin, Ying-Wu; Chen, Ze-Yuan] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

[Yuan, Hong; Tan, Xiangshi] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China.

[Yuan, Hong; Tan, Xiangshi] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China.

[Gao, Shu-Qin; Sun, Li-Juan; Lin, Ying-Wu] Univ South China, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Yu, Lu] Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China.

通讯机构：

[Lin, YW ] U

Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

Univ South China, Hengyang Med Sch, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

heme active site;heme proteins;protein engineering;covalent modification;X-ray structure

期刊：

ChemBioChem

ISSN：

1439-4227

年：

2024

卷：

期：

页码：

e202300678-

DOI：

10.1002/cbic.202300678

基金类别：

National Natural Science Foundation of China; [32171270]; [21977042]; [21977017]

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

摘要：

Covalent modification: A facial approach was developed to regulate the heme active site of heme protein by cavity generation, followed by covalent modifications, as shown by the two case studies using myoglobin as a model protein. Abstract Using myoglobin (Mb) as a model protein, we herein developed a facial approach to modifying the heme active site. A cavity was first generated in the heme distal site by F46 C mutation, and the thiol group of Cys46 was then used for covalently linked to exogenous ligands, 1H‐1,2,4‐triazole‐3‐thiol and 1‐...

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