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Sensitivity of Sniffer Dogs for aDiagnosis of Parkinson's Disease: A Diagnostic Accuracy Study

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成果类型:
期刊论文
作者:
Gao, Chang-Qing;Wang, Shan-Ni;Wang, Mei-Mei;Li, Jing-Jing;Qiao, Jiao-Jiao;...
通讯作者:
Guo, J.-F.;Gao, C.-Q.
作者机构:
[Xiang, Ya-Qin; Qiao, Jiao-Jiao; Gao, Chang-Qing; Li, Jing-Jing; Huang, Juan-Juan; Wang, Shan-Ni; Wang, Mei-Mei; Zhang, Xu-Xiang; Xu, Qian; Guo, Ji-Feng; Tang, Bei-Sha; Wang, Jun-Ling; Liu, Zheng-Hua; Shen, Lu] Cent South Univ, Xiang Ya Hosp, Dept Neurol, Xiang Ya Rd 87, Changsha 410008, Peoples R China.
[Qiao, Jiao-Jiao; Gao, Chang-Qing; Li, Jing-Jing; Wang, Shan-Ni; Wang, Mei-Mei] Cent South Univ, Xiang Ya Hosp, Ctr Studies Lab Anim, Changsha, Peoples R China.
[Qiao, Jiao-Jiao] Cent South Univ, Sch Basic Med Sci, Dept Microbiol, Changsha, Peoples R China.
[Hu, Ping-An; Wang, Jian-Gang; Chen, Zhi-Heng] Cent South Univ, Xiang Ya Hosp 3, Dept Hlth Prevent, Changsha, Peoples R China.
[Lei, Li-Fang; Zhang, Ru-Xu; Song, Zhi; Gu, Shao-Juan] Cent South Univ, Xiang Ya Hosp 3, Dept Neurol, Changsha, Peoples R China.
通讯机构:
[Chang-Qing Gao ; Ji-Feng Guo ] D
Department of Neurology, Xiang-Ya Hospital, Central South University, Changsha, China<&wdkj&>Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, China<&wdkj&>Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, China<&wdkj&>National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China<&wdkj&>Department of Neurology, Xiang-Ya Hospital, Central South University, Changsha, China<&wdkj&>Center for Studies in Laboratory Animals, Xiang-Ya Hospital, Central South University, Changsha, China<&wdkj&>National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
语种:
英文
期刊:
Movement Disorders
ISSN:
0885-3185
年:
2022
卷:
37
期:
9
页码:
1807-1816
基金类别:
We thank Professor Nai-Chang Yu, Xuan Wu Hospital, Beijing, China; Professor Postuma, Department of Neurology, Montreal General Hospital, Montreal, Canada; Professor Takwoingi, Test Evaluation Research Group, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham; and Dr. Laura Wu, UTMB (University of Texas Medical Branch) Neurology Department for their invaluable comments and suggestions on the manuscript. We thank all the participants who volunteered for this study. We also thank Mr. Ying-Qing Li and Mr. Ling-Jun Meng who were involved in training the dogs in the early stages of the work. We are grateful to all the nurses in the eighth ward of the Department of Neurology of the Third Xiang-Ya Hospital who helped us to collect samples in the early stage of the study. We extend our gratitude to Professor Xing-Jun Jiang and his team and all other people who worked with us in recent years caring for our dogs as well as those who have cared about and supported our research.
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Background: The diagnostic criteria for Parkinson's disease (PD) remain complex, which is especially problematic for nonmovement disorder experts. A test is required to establish a diagnosis of PD with improved accuracy and reproducibility. Objective: The study aimed to investigate the sensitivity and specificity of tests using sniffer dogs to diagnose PD. Methods: A prospective, diagnostic case-control study was conducted in four tertiary medical centers in China to evaluate the accuracy of sniffer dogs to distinguish between 109 clinically es...

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