Aldo-Keto Reductase Family 1 Member B10 Inhibitors: Potential Drugs for Cancer Treatment

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成果类型：

期刊论文

作者：

Huang, Li;He, Rongzhang;Luo, Weihao;Zhu, Yuan-Shan;Li, Jia;...

通讯作者：

Hu, Zheng;Luo, Dixian

作者机构：

[Hu, Z; Luo, DX; Li, Jia; Huang, Li; Hu, Zheng; He, Rongzhang; Luo, Weihao; Zhang, Xi; Luo, Dixian; Tan, Tan] Univ South China, Natl & Local Joint Engn Lab High Mol Diag Technol, Collaborat Res Ctr Postdoctoral Mobile Stn, Translat Med Inst,Affiliated Peoples Hosp Chenzho, Chenzhou 432000, Peoples R China.

[Huang, Li; Zhang, Xi; Luo, Dixian; Tan, Tan] Univ South China, Affiliated Peoples Hosp Chenzhou 1, Ctr Clin Pathol, Chenzhou 432000, Peoples R China.

[Zhu, Yuan-Shan; Hu, Zheng] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410078, Hunan, Peoples R China.

[Zhu, Yuan-Shan; Hu, Zheng] Cent S Univ, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China.

[Zhu, Yuan-Shan; Hu, Zheng] Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Hu, Z; Luo, DX] U

Univ South China, Natl & Local Joint Engn Lab High Mol Diag Technol, Collaborat Res Ctr Postdoctoral Mobile Stn, Translat Med Inst,Affiliated Peoples Hosp Chenzho, Chenzhou 432000, Peoples R China.

语种：

英文

关键词：

AKR1B10;Aldo-keto reductase;ARL-1;cancer;chemoresistance;inhibitors.

期刊：

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY

ISSN：

1574-8928

年：

2016

卷：

期：

页码：

184-196

DOI：

10.2174/1574892811888160304113346

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372825, 81300429]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2015M582340]; Strategic New Industrialization Special Project of Hunan Province [XCQZ2015-68]; Education Department Project of Hunan Province [13C882]; Health Department project of the Hunan Province [B2012-157]; Young Natural Science Foundation of Chenzhou [CZ2013063]; Foreign Intelligence Introduction Project [CCSZ2015-116]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Cytosolic NADPH-dependent reductase AKR1B10 is a member of the aldo-keto reductase (AKR) superfamily. This enzyme is normally expressed in the gastrointestinal tract. However, it is overexpressed in many solid tumors, such as hepatocarcinoma, lung cancer and breast cancer. AKR1B10 may play a role in the formation and development of carcinomas through multiple mechanisms including detoxification of cytotoxic carbonyls, modulation of retinoic acid level, and regulation of cellular fatty acid synthesis and lipid metabolism. Studies have suggested that AKR1B10 may be a useful biomarker for cancer ...

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