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Apolipoprotein-AI and AIBP synergetic anti-inflammation as vascular diseases therapy: the new perspective

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成果类型:
期刊论文
作者:
Jackson, Ampadu O.;Rahman, Ganiyu A.;Long, Shiyin
通讯作者:
Shiyin Long
作者机构:
[Jackson, Ampadu O.; Long, Shiyin] Univ South China, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.
[Jackson, Ampadu O.] Univ South China, Int Coll, Hengyang 421001, Hunan, Peoples R China.
[Rahman, Ganiyu A.; Jackson, Ampadu O.] Univ Cape Coast, Cape Coast Teaching Hosp, Sch Med, Dept Surg, Cape Coast, Ghana.
通讯机构:
[Long, Shiyin] D
Department of Biochemistry and Molecular Biology, University of South China, Hengyang, 421001, Hunan Province, China.
语种:
英文
关键词:
ABC transporter A1;adenosine triphosphate;apolipoprotein a i binding protein;apolipoprotein A1;binding protein;unclassified drug;APOA1 protein, human;apolipoprotein A1;AUNIP protein, human;DNA binding protein;antiinflammatory activity;atherosclerosis;cell activation;cell function;coronary artery disease;endoplasmic reticulum stress;endothelial progenitor cell;endothelium cell;homeostasis;human;hypertension;immunocompetent cell;macromolecule;oxidative stress;pathogenesis;protein expression;protein function;protein structure;Review;vascular disease;vascular energy homeostasis;vascular smooth muscle;vascular smooth muscle cell;inflammation;metabolism;pathology;signal transduction;vascular disease;Apolipoprotein A-I;DNA-Binding Proteins;Humans;Inflammation;Signal Transduction;Vascular Diseases
期刊:
Molecular and Cellular Biochemistry
ISSN:
0300-8177
年:
2021
卷:
476
期:
8
页码:
3065-3078
基金类别:
This research was supported by the Natural Science Foundation of Hunan Province, China (2018JJ2346).
机构署名:
本校为第一机构
院系归属:
化学化工学院
药学与生物科学学院
摘要:
Vascular diseases (VDs) including pulmonary arterial hypertension (PAH), atherosclerosis (AS) and coronary arterial diseases (CADs) contribute to the higher morbidity and mortality worldwide. Apolipoprotein A-I (Apo A-I) binding protein (AIBP) and Apo-AI negatively correlate with VDs. However, the mechanism by which AIBP and apo-AI regulate VDs still remains unexplained. Here, we provide an overview of the role of AIBP and apo-AI regulation of vascular diseases molecular mechanisms such as vascular energy homeostasis imbalance, oxidative and en...

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