期刊论文

Wu, Yi-Jun

英文

Chemico-Biological Interactions

0009-2797

2017

272

Suppl.28

21-27

10.1016/j.cbi.2017.04.023

CAS Strategic Priority Research Program [XDB14040203]; Main Direction Program [KZCX2-EW-404]; National High Technologies RD Program [2006AA06Z423]

本校为其他机构

Carbamates and pyrethroids are widely used pesticides. However, their joint toxicity at low doses with long-term exposure remains unknown. Therefore, we investigated the subchronic joint hepatotoxicity of the two representative pesticides within these two classes, i.e., propoxur (PR) and permethrin (PE) in rats. The male Wistar rats were orally treated with three different doses of PR, PE and their mixtures for 90 consecutive days. Liver weight, serum clinical chemistry parameters and histopathological changes were measured to access the hepatotoxicity. In addition, oxidative stress markers in...