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MicroRNA-182 promotes lipoprotein lipase expression and atherogenesisby targeting histone deacetylase 9 in apolipoprotein E-knockout mice

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成果类型:
期刊论文
作者:
Cheng, Hai-Peng;Gong, Duo;Zhao, Zhen-Wang;He, Ping-Ping;Yu, Xiao-Hua;...
通讯作者:
Yin, Wei-Dong;Tang, Chao-Ke
作者机构:
[Gong, Duo; Cheng, Hai-Peng; He, Ping-Ping; Ouyang, Xin-Ping; Xia, Xiao-Dan; Zhang, Min; Tang, Chao-Ke; Tan, Yu-Lin; Zhao, Zhen-Wang; Yu, Xiao-Hua; Li, Liang; Yin, Wei-Dong; Xie, Wei; Huang, Chong; Chen, Ling-Yan] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang, Hunan, Peoples R China.
[Zhang, Xin; Wang, Zong-bao] Univ South China, Sch Pharm & Life Sci Coll, Hengyang, Hunan, Peoples R China.
[Ye, Qiong; Tian, Guo-Ping] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Hengyang, Hunan, Peoples R China.
[Ye, Qiong; Tian, Guo-Ping] Univ South China, Dept Cardiovasc Med, Affiliated Hosp 2, Hengyang, Hunan, Peoples R China.
[Zheng, Xi-Long] Univ Calgary, Libin Cardiovasc Inst Alberta, Cumming Sch Med, Dept Biochem & Mol Biol,Hlth Sci Ctr, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
通讯机构:
[Yin, WD; Tang, CK] U
Univ South China, Inst Cardiovasc Res, 28 W Chengsheng Rd, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Atherosclerosis;Histone deacetylase 9 (HDAC9);Inflammation;Lipoprotein lipase (LPL);MicroRNA-182
期刊:
Circulation Journal
ISSN:
1346-9843
年:
2018
卷:
82
期:
1
页码:
28-38
基金类别:
Received November 16, 2016; revised manuscript received June 3, 2017; accepted July 6, 2017; released online August 29, 2017 Time for primary review: 28 days Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province (H.-P.C., D.G., Z.-W.Z., P.-P.H., X.-H.Y., C.H., L.-Y.C., W.X., M.Z., L.L., X.-D.X., X.-P.O., Y.-L.T., W.-D.Y., C.-K.T.), School of Pharmacy and Life Science College (X.Z., Z.-b.W.), Medical Research Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan; Department of Cardiovascular Medicine, Second Affiliated Hospital of University of South China, Hengyang, Hunan (Q.Y., G.-P.T.), China; and Department of Biochemistry and Molecular Biology, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Health Sciences Center, 3330 Hospital Dr. NW, Calgary, Alberta (X.-L.Z.), Canada T2N4N1 The first three authors contributed equally to this work (H.-P.C., D.G., Z.-W.Z.).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
Background: Lipoprotein lipase (LPL) expressed in macrophages plays an important role in promoting the development of atherosclerosis or atherogenesis. MicroRNA-182 (miR-182) is involved in the regulation of lipid metabolism and inflammation. However, it remains unclear how miR-182 regulates LPL and atherogenesis. Methods and Results: Using bioinformatics analyses and a dual-luciferase reporter assay, we identified histone deacetylase 9 (HDAC9) as a target gene of miR-182. Moreover, miR-182 upregulated LPL expression by directly targeting HDAC9...

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