C-type natriuretic peptide inhibiting vascular calcification might involve decreasing bone morphogenic protein 2 and osteopontin levels

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成果类型：

期刊论文

作者：

Chen, Jing-Jing;Zhang, Jing;Cai, Yan;Zhou, Ye-Bo;Wen, Ge-Bo;...

通讯作者：

Jiang, Zhi-Sheng

作者机构：

[Chen, Jing-Jing; Jiang, Zhi-Sheng; Wen, Ge-Bo] Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.

[Chen, Jing-Jing] Jinan Fifth Peoples Hosp, Jinan, Shandong, Peoples R China.

[Zhang, Jing] Beijing Normal Univ, Sch PE & Sports Sci, Beijing 100875, Peoples R China.

[Tang, Chao-Shu; Zhou, Ye-Bo; Cai, Yan; Qi, Yong-Fen] Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100871, Peoples R China.

通讯机构：

[Jiang, Zhi-Sheng] U

Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

C-type natriuretic peptide;Vascular calcification;Vascular smooth muscle cells

期刊：

Molecular and Cellular Biochemistry

ISSN：

0300-8177

年：

2014

卷：

392

期：

1-2

页码：

65-76

DOI：

10.1007/s11010-014-2019-1

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30570766, 30971169, 81170277]; Department of Education of Hunan Province [05A043]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Human Province [2008-244]; Ministry of Education, P. R. ChinaMinistry of Education, China; University of South China

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Vascular calcification (VC) is highly associated with increased morbidity and mortality in patients with advanced chronic kidney disease. Paracrine/autocrine factors such as vasoactive peptides are involved in VC development. Here, we investigated the expression of the novel peptide C-type natriuretic peptide (CNP) in the vasculature, tested its ability to prevent VC in vivo and in vitro, and examined the mechanism involved. Rat aortic VC was induced by vitamin D3 plus nicotine (VDN). CNP (500 ng/kg/h) was administered by mini-osmotic pump. Cal...

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C-type natriuretic peptide inhibiting vascular calcification might involve decreasing bone morphogenic protein 2 and osteopontin levels

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