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Targeted Metabolomics and Widely Targeted Quantitative Lipidomics Reveal Synergistic Metabolic Interference in Adipose Tissue After the Combined Chronic Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, and Fructose in Male Rats

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成果类型:
期刊论文
作者:
Liu, Xiaocheng;Zeng, Liu;Liu, Xu;Zhou, Yunxia;Rang, Ouyan;...
通讯作者:
Wang, M
作者机构:
[Liu, Xiaocheng; Zeng, Liu; Rang, Ouyan; Wang, Mu; Zhou, Yunxia] Univ South China, Affiliated Nanhua Hosp, Clin Mass Spectrometry Lab, Clin Res Inst,Hengyang Med Sch, Hengyang, Peoples R China.
[Liu, Xu] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.
通讯机构:
[Wang, M ] U
Univ South China, Affiliated Nanhua Hosp, Clin Mass Spectrometry Lab, Clin Res Inst,Hengyang Med Sch, Hengyang, Peoples R China.
语种:
英文
关键词:
Bisphenol F;Bisphenol S;fructose;synergistic interference;targeted metabolomics;widely targeted quantitative lipidomics
期刊:
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
ISSN:
1095-6670
年:
2025
卷:
39
期:
8
页码:
e70440
基金类别:
This study was supported by the Key Project of Hunan Provincial Natural Science Foundation (No. 2025JJ30049), Key Project of Hunan provincial science and technology innovation (No. 2020sk1012); Natural Science Foundation of Hunan Province (No. 2022JJ30547) [2025JJ30049]; Key Project of Hunan Provincial Natural Science Foundation [2020sk1012]; Key Project of Hunan provincial science and technology innovation [2022JJ30547]; Natural Science Foundation of Hunan Province [Z2023160]; National Key Clinical Specialty Scientific Research Project
机构署名:
本校为第一且通讯机构
院系归属:
公共卫生学院
摘要:
The combined effect of environmental exposure and dietary behavior plays a vital role in the occurrence of diseases. Bisphenol S (BPS) and bisphenol F (BPF) are the most commonly used substitutes for bisphenol A (BPA). Previous studies have shown that the combined exposure to BPA and fructose caused significant disturbances in glycolipid metabolism in adipose tissue, however, the interference caused by the combined exposure to BPS and fructose or BPF and fructose on adipose tissue is still unclear. In the present study, we performed a integrate...

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