期刊论文

Wu, Minghua

英文

Brain Research

0006-8993

2011

1390

21-32

10.1016/j.brainres.2011.03.034

National Key Project of Scientific Research Program in China [2006CB910504]; 111 ProjectMinistry of Education, China - 111 Project [111-2-12]; National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30770825, 30901539, 30901718]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-08-0562]

本校为其他机构

LRRC4 is not only a brain-specific gene, but it has also been identified as a tumor suppressor gene for glioma. Promoter methylation of LRRC4 is frequently involved in the inactivation in glioma. MiRNA-mediated gene regulation has recently been demonstrated to play an important role in multiple biological processes related to cancer, including glioma. In this study, we demonstrated that a small regulatory microRNA, hsa-miR-381, an "oncomir", had a major role in glioma progression and that LRRC4 was a target of hsa-miR-381. By regulating LRRC4, ...