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Ketamine for post-traumatic stress disorders and it's possible therapeutic mechanism

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Asim, Muhammad;Wang, Bing;Hao, Bo;Wang, Xiaoguang

通讯作者：

Xiaoguang Wang

作者机构：

[Asim, Muhammad] City Univ Hong Kong, Dept Biomed Sci, Key Lab Neurosci, Kowloon Tong, Hong Kong, Peoples R China.

[Hao, Bo; Wang, Xiaoguang; Asim, Muhammad] Sun Yat Sen Univ, Fac Forens Med, Zhongshan Sch Med, Guangzhou 510080, Guangdong, Peoples R China.

[Hao, Bo; Wang, Xiaoguang; Asim, Muhammad] Sun Yat Sen Univ, Guangdong Prov Translat Forens Med Engn Technol R, Zhongshan Sch Med, Guangzhou, Peoples R China.

[Wang, Bing] Univ South China, Affiliated Hosp 2, Dept Neurosurg, Hengyang, Peoples R China.

[Hao, Bo; Wang, Xiaoguang] Sun Yat Sen Univ, Zhongshan Sch Med, Guangdong Prov Key Lab Brain Funct & Dis, Guangzhou, Peoples R China.

通讯机构：

[Xiaoguang Wang] F

Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China<&wdkj&>Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China<&wdkj&>Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China

语种：

英文

关键词：

Ketamine;PTSD;CCK;NMDAR

期刊：

Neurochemistry International

ISSN：

0197-0186

年：

2021

卷：

146

期：

页码：

105044

DOI：

10.1016/j.neuint.2021.105044

基金类别：

Natural Science Foundation of Guangdong Province ChinaNational Natural Science Foundation of Guangdong Province [2017A030313095]; Pearl River S and T Nova Program of Guangzhou [201610010154]; Natural Science Foundation of Hunan Province ChinaNatural Science Foundation of Hunan Province [2018JJ3461]

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摘要：

Posttraumatic stress disorder (PTSD) is a devastating medical illness, for which currently available pharmacotherapies have poor efficacy. Accumulating evidence from clinical and preclinical animal investigations supports that ketamine exhibits a rapid and persistent effect against PTSD, though the underlying molecular mechanism remains to be clarified. In this literature review, we recapitulate the achievements from early ketamine studies to the most up-to-date discoveries, with an effort to discuss an inclusive therapeutic role of ketamine for PTSD treatment and its possible therapeutic mech...

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