New mechanisms: From lactate to lactylation to rescue heart failure

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成果类型：

期刊论文

作者：

Yi, Linfeng;Tang, Dan;Xiang, Xing;Xiao, Chungang;Tang, Huifang*;...

通讯作者：

Tang, Huifang;Huang, H

作者机构：

[Tang, Dan; Xiang, Xing; Yi, Linfeng] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Inst Microbiol & Infect Dis,Dept Clin Lab Med, Hengyang, Hunan, Peoples R China.

[Tang, Huifang; Huang, Hong; Tang, Dan; Xiang, Xing; Yi, Linfeng; Tang, HF] Clin Res Ctr Myocardial Injury Hunan Prov, Hengyang, Hunan, Peoples R China.

[Tang, Huifang; Huang, Hong; Tang, Dan; Xiang, Xing; Yi, Linfeng; Tang, HF] Univ South China, Affiliated Hosp 1, Inst Cardiovasc Dis, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

[Tang, Huifang; Huang, Hong; Tang, Dan; Xiang, Xing; Yi, Linfeng; Tang, HF] Univ South China, Hunan Prov Key Lab Multiom & Artificial Intelligen, Hengyang, Hunan, Peoples R China.

[Xiao, Chungang] Hunan Univ Med Gen Hosp, Dept Orthoped, Huaihua, Hunan, Peoples R China.

通讯机构：

[Huang, H ; Tang, HF] C

Clin Res Ctr Myocardial Injury Hunan Prov, Hengyang, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Inst Cardiovasc Dis, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

Univ South China, Hunan Prov Key Lab Multiom & Artificial Intelligen, Hengyang, Hunan, Peoples R China.

Univ South China, Hunan Prov Key Lab Multiom & Artificial Intelligen, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Titin;heart failure;lactylation;sarcomeric structure and function;α-MHC

期刊：

BioScience Trends

ISSN：

1881-7815

年：

2024

卷：

期：

页码：

105-107

DOI：

10.5582/bst.2024.01000

基金类别：

Natural Science Foundation of Hunan Province [2023JJ30547, 2023JJ60051, 2021JJ70042]; Major Project of Hunan Provincial Health Commission [W20243224, W20241008]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Lactylation of alpha-myosin heavy chain (alpha-MHC) has recently been reported to preserve sarcomeric structure and function and attenuate the development of heart failure. Specifically, lactylation enhanced the interaction of alpha-MHC with the sarcomeric protein Titin, thereby maintaining normal sarcomeric structure and myocardial contractile function. Furthermore, the administration of lactate or inhibition of lactate efflux potentially treats heart failure by restoring lactylation of alpha-MHC and the interaction of alpha-MHC with Titin. This finding highlights the significant role of alph...

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New mechanisms: From lactate to lactylation to rescue heart failure

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