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A Cascade Nanozyme with Amplified Sonodynamic Therapeutic Effects through Comodulation of Hypoxia and Immunosuppression against Cancer

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成果类型:
期刊论文
作者:
Tao, Na;Li, Huihuang;Deng, Liu*;Zhao, Senfeng;Ouyang, Jiang;...
通讯作者:
Deng, Liu;Liu, YN
作者机构:
[Deng, Liu; Wen, Mei; Zhao, Senfeng; Liu, You-Nian; Zeng, Ke; Chen, Wansong; Tao, Na; Ouyang, Jiang] Cent South Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Micro & Nano Mat Interface Sci, Changsha 410083, Hunan, Peoples R China.
[Li, Huihuang] Cent South Univ, Xiangya Hosp, Dept Urol, Changsha 410083, Hunan, Peoples R China.
[Zeng, Ke; Wei, Chuanwan] Univ South China, Coll Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Deng, L; Liu, YN ] C
Cent South Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Micro & Nano Mat Interface Sci, Changsha 410083, Hunan, Peoples R China.
语种:
英文
关键词:
tumor microenvironment adjustment;hypoxia alleviation;sonodynamic therapy;nanozymes;ROS
期刊:
ACS Nano
ISSN:
1936-0851
年:
2022
卷:
16
期:
1
页码:
485-501
基金类别:
This work was supported by the National Natural Science Foundation of China (No. 21878342 and 21807117), the Hunan Provincial Science and Technology Plan Project, China (No. 2019TP1001 and 2020JJ3044), and the State Key Laboratory of Powder Metallurgy, Central South University, Changsha, China.
机构署名:
本校为其他机构
院系归属:
化学化工学院
摘要:
The tumor microenvironment (TME) featured by immunosuppression and hypoxia is pivotal to cancer deterioration and metastasis. Thus, regulating the TME to improve cancer cell ablation efficiency has received extensive interest in oncotherapy. However, to reverse the immunosuppression and alleviate hypoxia simultaneously in the TME are major challenges for effective cancer therapy. Herein, a multifunctional platform based on Au nanoparticles and a carbon dots modified hollow black TiO2 nanosphere (HABT-C) with intrinsic cascade enzyme mimetic act...

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