期刊论文

Li, Lanfang

英文

Medical Hypotheses

0306-9877

2016

90

6-10

10.1016/j.mehy.2016.02.017

'National Natural Science Foundation of China' - 'China'National Natural Science Foundation of China (NSFC) [81470434, 81270420]; 'China Postdoctoral Science Foundation' - 'China'China Postdoctoral Science Foundation [2014M560647, 2015T80875]; 'Hunan Province Cooperative innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department document)' - 'China, Hunan' [2014-405]; Construct Program of the Key Discipline in Hunan Province; 'Hunan Provincial Natural Science Foundation of China' - 'China, Hunan' [14JJ3102]; 'Hunan Provincial Science and Technology Project' - 'China, Hunan' [2015RS4040]; 'Administration of Traditional Chinese Medicine of Hunan Province' - 'China, Hunan' [201578]; 'Health and Family Planning Commission of Hunan Province' - 'China, Hunan' [B2015-48]

本校为第一且通讯机构

The G protein-coupled receptor APJ elicits cellular response to diverse extracellular stimulus. Accumulating evidence reveals that APJ receptor plays a prominent role in the cardiomyocyte adapting to hypertrophic stimulation. At present, it remains obscure that the regulatory mechanism of APJ receptor in myocardial hypertrophy. The natural endogenous ligands apelin and Elabela as well as agonists maintain high affinity for the APJ receptor and drive its internalization. Ligand-activated receptor internalization is mainly performed by clathrin-mediated endocytic pathway. Simultaneously, clathri...