Regulation of both the structure and function by a de novo designed disulfide bond: a case study of heme proteins in myoglobin

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成果类型：

期刊论文

作者：

Yin, Lu-Lu;Yuan, Hong;Du, Ke-Jie;He, Bo;Gao, Shu-Qin;...

通讯作者：

Lin, Ying-Wu

作者机构：

[Yin, Lu-Lu; Lin, Ying-Wu; Du, Ke-Jie; He, Bo] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

[Yuan, Hong; Tan, Xiangshi] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China.

[Yuan, Hong; Tan, Xiangshi] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China.

[Gao, Shu-Qin; Wen, Ge-Bo; Lin, Ying-Wu] Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.

通讯机构：

[Lin, Ying-Wu] U

Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

Chemical Communications

ISSN：

1359-7345

年：

2018

卷：

期：

页码：

4356-4359

DOI：

10.1039/c8cc01646a

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21701081, 31370812]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [15A158]

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

摘要：

A de novo designed intramolecular disulfide bond in myoglobin, resembling that in cytoglobin without structural evidence, was confirmed by an X-ray structure for the first time and was demonstrated to regulate both the structure and function of this protein, which fulfills the design of an artificial dehaloperoxidase, with an act...

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Regulation of both the structure and function by a de novo designed disulfide bond: a case study of heme proteins in myoglobin

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