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Microcystin-LR Induces and Aggravates Colitis through NLRP3 Inflammasome-Mediated Pyroptosis in Mice

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成果类型:
期刊论文
作者:
Yang, Yue;Gong, Pan;Long, Xiuyan;Jiang, Yuanjuan;Ye, Mingmei;...
通讯作者:
Tian, L;Yang, F
作者机构:
[Long, Xiuyan; Gong, Pan; Ye, Mingmei; Tian, Li; Yang, Yue; Tao, Sifan] Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha 410078, Peoples R China.
[Yang, F; Jiang, Yuanjuan; Yang, Fei] Univ South China, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.
[Su, Yahui] Cent South Univ, Xiangya Sch Med, 172 Tongzipo Rd, Changsha 410078, Peoples R China.
[Yang, F; Yang, Fei] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang 421001, Peoples R China.
通讯机构:
[Tian, L ] C
[Yang, F ] U
Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha 410078, Peoples R China.
Univ South China, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.
Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
microcystin-LR;inflammatory bowel disease;NLRP3 inflammasome;pyroptosis
期刊:
TOXINS
ISSN:
2072-6651
年:
2023
卷:
15
期:
7
页码:
447-
基金类别:
Y.Y.: conceptualization, investigation, methodology, project administration, writing—review and editing; P.G.: formal analysis, validation, visualization, writing—original draft; X.L.: visualization; Y.J.: investigation and validation; M.Y.: writing—review and editing; S.T.: writing—review and editing; Y.S.: writing—original draft; F.Y.: conceptualization, funding acquisition, project administration, resources, supervision, writing—review and editing; L.T.: conceptualization, funding acquisition, project administration, resources, supervision, writing—review and editing. All authors have read and agreed to the published version of the manuscript. This work was supported by the Research Programs of Hunan Hygienism and Health Committee (202103031923); the Scientific Research Program of the Human Administration Bureau of Chinese Medicine (D2022026), China; Key Research and Development Projects in Hunan Province (2022SK2089), China; the Huxiang Youth Talent Program (2021RC3107), China.
机构署名:
本校为通讯机构
院系归属:
公共卫生学院
摘要:
Inflammatory bowel disease (IBD) is a chronic, lifelong gastrointestinal disease, characterized by periods of activity and remission. The etiology of IBD is closely related to environmental factors. Previous studies have shown that the cyanotoxin microcystin-LR (MC-LR) causes intestinal damage, even IBD. To explore MC-LR's effects and potential mechanisms on IBD occurrence and development, we used dextran-sulfate sodium gavage (DSS) and MC-LR together for the first time in mice. There were four groups of mice: (A) mice given PBS gavage (control, CT); (B) mice given 3% DSS gavage (DSS); (C) mic...

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