Dendrobium nobile Lindl polysaccharides improve testicular spermatogenic function in streptozotocin-induced diabetic rats

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期刊论文

作者：

Lei, Xiaocan;Huo, Peng;Xie, Yuan-jie;Wang, Yaohui;Liu, Guanghai;...

通讯作者：

Mo, ZC;Zhang, S

作者机构：

[Xie, Yuan-jie; Mo, Zhong-cheng; Lei, Xiaocan] Univ South China, Clin Anat & Reprod Med Applicat Inst, Dept Histol & Embryol, Hengyang 421001, Peoples R China.

[Huo, Peng] Guilin Med Univ, Sch Publ & Hlth, Guilin, Peoples R China.

[Liu, Guanghai; Shi, Qingxiang; Wang, Yaohui] Zunyi Med Univ, Sch Basic Med Sci, Zunyi, Guizhou, Peoples R China.

[Zhang, Shun; Tu, Haoyan; Zhang, S] Guilin Med Univ, Affiliated Hosp, Dept Reprod Med Ctr, Guilin 541001, Peoples R China.

通讯机构：

[Mo, ZC ] U

[Zhang, S ] G

Univ South China, Clin Anat & Reprod Med Applicat Inst, Dept Histol & Embryol, Hengyang 421001, Peoples R China.

Guilin Med Univ, Affiliated Hosp, Dept Reprod Med Ctr, Guilin 541001, Peoples R China.

语种：

英文

关键词：

apoptosis;Dendrobium nobile Lindl;diabetic rats;PCNA;polysaccharides;testes

期刊：

MOLECULAR REPRODUCTION AND DEVELOPMENT

ISSN：

1040-452X

年：

2022

卷：

期：

页码：

202-213

DOI：

10.1002/mrd.23556

基金类别：

China National Natural Science FundNational Natural Science Foundation of China (NSFC) [81860733, 81960274]; Science and Technology Fund of Guizhou province [Qian Basic [2019]1344]; Key Lab for Clinical Anatomy & Reproductive Medicine of Hengyang City [2017KJ182]; Key Project of Guangxi Natural Science Foundation [2018GXNSFDA050003]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Dendrobium nobile Lindl polysaccharides (DNLP) exhibited various biological functions. This study aimed to investigate the protective effects of DNLP on testicular spermatogenic function in streptozotocin (STZ)-induced diabetic rats in comparison with metformin. The blood glucose level was significantly increased and the homeostatic model assessment for insulin resistance (HOMA-IR) aggravated markedly in diabetic rats. The weight of testis and epididymis, and the sperm number and motility were decreased in the diabetic rats. The pathologic changes occurred in the spermatogenic tubules along wi...

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Dendrobium nobile Lindl polysaccharides improve testicular spermatogenic function in streptozotocin-induced diabetic rats

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