Dendrobium nobile Lindl. polysaccharides improve follicular development in PCOS rats

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成果类型：

期刊论文

作者：

Zhang, Shun;Tu, Haoyan;Zhu, Jiamin;Liang, Aihong;Huo, Peng;...

通讯作者：

Chen, Xi;Lei, Xiaocan

作者机构：

[Zhang, Shun; Tu, Haoyan] Guilin Med Univ, Dept Reprod Med Ctr, Affiliated Hosp, Guilin 541001, Peoples R China.

[Chen, Xi; Lei, Xiaocan; Liang, Aihong; Chen, X] Univ South China, Clin Anat & Reprod Med Applicat Inst, Dept Histol & Embryol, Hengyang 421001, Peoples R China.

[Zhao, Meng; Zhu, Jiamin; Shan, Ke; He, Junyi] Zunyi Med Univ, Sch Basic Med Sci, Zunyi 563000, Guizhou, Peoples R China.

[Huo, Peng] Guilin Med Univ, Sch Publ & Hlth, Guilin 541004, Peoples R China.

通讯机构：

[Chen, X; Lei, XC] U

Univ South China, Clin Anat & Reprod Med Applicat Inst, Dept Histol & Embryol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Apoptosis;DNLP;Estrous cycle;PCNA;PCOS;Proliferation

期刊：

International Journal of Biological Macromolecules

ISSN：

0141-8130

年：

2020

卷：

149

页码：

826-834

DOI：

10.1016/j.ijbiomac.2020.01.196

基金类别：

The present study was supported by the China National Natural Science Fund (No. 81860733 and 81960274), The Science and Technology Fund of Guizhou province (No. Qian Basic [2019]1344), Key Lab for Clinical Anatomy & Reproductive Medicine of Hengyang City (2017KJ182), and Key Project of Guangxi Natural Science Foundation (No. 2018GXNSFDA050003), the Improving the Basic Ability of Young and Middle-aged University Teachers in Guangxi (No. 2017KY0477).

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Polycystic ovary syndrome (PCOS) is the most typical and common metabolic abnormalities in women of reproductive age. This study examined the protective effects of Dendrobium nobile Lindl. polysaccharides (DNLP) on ovarian follicular development in letrozole-induced PCOS rats and explored the underlying molecular mechanisms. The PCOS rats showed the increased body weight, serum testosterone and luteinizing hormone levels and insulin resistance. DNLP treatment reduced the body weight, serum testosterone level and insulin resistance, but failed to affect luteinizing hormone level in the PCOS rat...

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Dendrobium nobile Lindl. polysaccharides improve follicular development in PCOS rats

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