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Association of luteinizing hormone/choriogonadotropin receptor gene polymorphisms with polycystic ovary syndrome risk: a meta-analysis

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成果类型:
期刊论文
作者:
Zou, Ju;Wu, Daichao;Liu, Yan;Tan, Sijie*
通讯作者:
Tan, Sijie
作者机构:
[Liu, Yan; Zou, Ju] Univ South China, Dept Parasitol, Sch Med, Hengyang, Peoples R China.
[Tan, Sijie; Wu, Daichao] Univ South China, Dept Histol & Embryol, Sch Med, Inst Clin Anat & Reprod Med, Hengyang 421001, Peoples R China.
通讯机构:
[Tan, Sijie] U
Univ South China, Dept Histol & Embryol, Sch Med, Inst Clin Anat & Reprod Med, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
association;gene polymorphism;LHCGR;meta-analysis;PCOS
期刊:
Gynecological Endocrinology
ISSN:
0951-3590
年:
2019
卷:
35
期:
1
页码:
81-85
基金类别:
The authors would like to thank financial support from Key Lab for Clinical Anatomy & Reproductive Medicine of Hengyang City (2017KJ182). S. T. was also partially supported by a grant from University of South China (2014XQD22) and a fellowship from Chinese Scholarship Council while preparing this manuscript (201608430251).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
To investigate the association between Luteinizing hormone/choriogonadotropin receptor (LHCGR) gene polymorphisms and polycystic ovary syndrome (PCOS). A systematic literature search and meta-analysis using STATA software for included studies. Fourteen case-control studies containing rs13405728, rs4539842, and rs2293275 of LHCGR gene were included, which was comprised of 11,738 PCOS cases and 35,329 controls. Results of the meta-analysis showed a significant association between PCOS and rs13405728 (for G vs. A: OR = 0.735, 95% CI = 0.699–0.773...

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