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Opportunities and Challenges in Tumor Angiogenesis Research. Back and Forth Between Bench and Bed

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成果类型:
期刊论文
作者:
Qin, Li;Bromberg-White, Jennifer L.;Qian, Chao-Nan*
通讯作者:
Qian, Chao-Nan
作者机构:
[Qian, Chao-Nan; Qin, Li] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol S China, Guangzhou 510275, Guangdong, Peoples R China.
[Qin, Li] Univ S China, Inst Pharm & Pharmacol, Div Pharmacoprote, Hengyang, Hunan, Peoples R China.
[Qian, Chao-Nan; Bromberg-White, Jennifer L.] Van Andel Res Inst, Lab Canc & Dev Cell Biol, Grand Rapids, MI USA.
通讯机构:
[Qian, Chao-Nan] S
Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol S China, Guangzhou 510275, Guangdong, Peoples R China.
语种:
英文
关键词:
Angiogenesis;Microvessels;Tumor vasculature;Tumor-derived endothelial cells;Vasculogenesis
期刊:
Advances in Cancer Research
ISSN:
0065-230X
年:
2012
卷:
113
页码:
191-239
基金类别:
This work was supported by Grants from the State Key Program of National Natural Science Foundation of China (Grant No. 81030043), the Youth Science Fund of the National Natural Science Foundation of China (Grant No. 81000946), the National Key Sci-Tech Special Project of China (Grant No. 2008ZX10002-019), the Outstanding Youth Project of Educational Department of Hunan Province, China (Grant No. 10B090), and the Van Andel Foundation. We thank David Nadziejka, Grand Rapids, Michigan for critical reading of the manuscript.
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
Angiogenesis is essential for tumor growth and metastasis. Many signaling pathways are involved in regulating tumor angiogenesis, with the vascular endothelial growth factor pathway being of particular interest. The recognition of the heterogeneity in tumor vasculature has led to better predictions of prognosis through differential analyses of the vasculature. However, the clinical benefits from antiangiogenic therapy are limited, because many antiangiogenic agents cannot provide long-term survival benefits, suggesting the development of drug r...

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