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A key regulator of tumor-associated neutrophils: the CXCR2 chemokine receptor

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成果类型:
期刊论文
作者:
Kang, Wenyan;Wang, Chengkun;Wang, Minhui;Liu, Meiqi;Hu, Wei;...
通讯作者:
Yang, JL;Zhang, Y
作者机构:
[Yang, JL; Kang, Wenyan; Yang, Juanli] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Gynecol, Hengyang 421001, Hunan, Peoples R China.
[Zhang, Yang; Liang, Xiaoqiu; Kang, Wenyan; Wang, Chengkun; Wang, Minhui; Hu, Wei; Zhang, Y; Liu, Meiqi] Univ South China, Canc Res Inst, Hengyang Med Sch, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 420001, Hunan, Peoples R China.
通讯机构:
[Yang, JL ; Zhang, Y ] U
Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Gynecol, Hengyang 421001, Hunan, Peoples R China.
Univ South China, Canc Res Inst, Hengyang Med Sch, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 420001, Hunan, Peoples R China.
语种:
英文
关键词:
CXCR2;Neutrophils;Inflammation;Pathway;Therapy
期刊:
Journal of Molecular Histology
ISSN:
1567-2379
年:
2024
卷:
55
期:
6
页码:
1051-1061
基金类别:
This work was supported by The National Natural Science Foundation of China(NO.81472449).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
In recent years, with the advance of research, the role of tumor-associated neutrophils (TANs) in tumors has become a research hotspot. As important effector cells in the innate immune system, neutrophils play a key role in the immune and inflammatory responses of the body. As the first line of defense against bacterial and fungal infections, neutrophils have the ability to kill invading pathogens. In the pathological state of malignant tumors, the phenotype of neutrophils is altered and has an important regulatory function in tumor development. The C-X-C motif chemokine receptor 2(CXCR2) is a...

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