Ferritinophagy activation and sideroflexin1-dependent mitochondria iron overload is involved in apelin-13-induced cardiomyocytes hypertrophy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tang, Mingzhu;Huang, Zhen;Luo, Xuling;Liu, Meiqing;Wang, Lingzhi;...

通讯作者：

Li, Lanfang;Wu, Di;Chen, Linxi

作者机构：

[Huang, Shifang; Luo, Xuling; Tang, Mingzhu; Li, Lanfang; Wu, Di; Chen, Linxi; Huang, Zhen; Liu, Meiqing; Qi, Zhihao; Wang, Lingzhi] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.

[Zhong, Jiuchang] Capital Med Univ, Beijing Chaoyang Hosp, Heart Ctr, Beijing 100020, Peoples R China.

[Zhong, Jiuchang] Capital Med Univ, Beijing Chaoyang Hosp, Beijing Key Lab Hypertens, Beijing 100020, Peoples R China.

[Chen, Jian-Xiong] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA.

通讯机构：

[Li, LF; Wu, D; Chen, LX] U

Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Apelin-13;Cardiomyocytes hypertrophy;Ferritin;Ferritinophagy;Mitochondria iron overload;ROS;sideroflexin1

期刊：

Free Radical Biology and Medicine

ISSN：

0891-5849

年：

2019

卷：

134

页码：

445-457

DOI：

10.1016/j.freeradbiomed.2019.01.052

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81703515, 81670265, 81503074]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Excess iron accumulation and cardiac oxidative stress have been shown as important mediators of cardiac hypertrophy, whereas it remains largely elusive about the occurrence of mitochondrial iron overload and its significance during cardiac hypertrophy. In the present study, we aim to investigate the role of NCOA4-mediated ferritinophagy and SFXN1-dependent mitochondria iron overload in apelin-13-induced cardiomyocytes hypertrophy. Apelin-13 significantly promotes ferric citrate (FAC)-induced total cellular and mitochondria ion production, as well as mitochondria ROS contents. Mechanistically, ...

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Ferritinophagy activation and sideroflexin1-dependent mitochondria iron overload is involved in apelin-13-induced cardiomyocytes hypertrophy

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