A breast cancer classification and immune landscape analysis based on cancer stem-cell-related risk panel

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成果类型：

期刊论文

作者：

Hu, Haihong;Zou, Mingxiang;Hu, Hongjuan;Hu, Zecheng;Jiang, Lingxiang;...

通讯作者：

Zhang, TL

作者机构：

[Zhang, Taolan; Hu, Haihong; Zhan, Wendi; Zhang, TL; Zhu, Hongxia] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang 421000, Hunan, Peoples R China.

[Zhang, Taolan; Hu, Haihong; Zhan, Wendi; Zhang, TL; Zhu, Hongxia] Univ South China, Hengyang Med Coll, Sch Pharm, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Taolan; Hu, Haihong; Zhang, TL] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Phase 1 Clin Trial Ctr, Hengyang 421000, Hunan, Peoples R China.

[Zou, Mingxiang] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Spine Surg, Hengyang 421000, Hunan, Peoples R China.

[Hu, Hongjuan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Publ Hlth Serv, Hengyang 421000, Hunan, Peoples R China.

通讯机构：

[Zhang, TL ] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang 421000, Hunan, Peoples R China.

Univ South China, Hengyang Med Coll, Sch Pharm, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Phase 1 Clin Trial Ctr, Hengyang 421000, Hunan, Peoples R China.

语种：

英文

期刊：

npj Precision Oncology

ISSN：

2397-768X

年：

2023

卷：

期：

页码：

130

DOI：

10.1038/s41698-023-00482-w

基金类别：

National Natural Science Foundation of China; Natural Science Foundation of Hunan Province [82003802, 82002364]; Natural Science Foundation for Excellent Youth Scholars of Hunan Province [2019JJ50542, 2023JJ50156, 2021JJ40509]; Science and Technology Program of Hunan Health Commission [2023JJ20035]; Science and technology innovation Program of Hunan Province [20201978]; China Scholarship Council [2023RC3172]; Clinical Research 4310 Program of First Affiliated Hospital of University of South China [201808430085]; Science and technology innovation Program of Hengyang City [20224310NHYCG04]; [202250045223]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

This study sought to identify molecular subtypes of breast cancer (BC) and develop a breast cancer stem cells (BCSCs)-related gene risk score for predicting prognosis and assessing the potential for immunotherapy. Unsupervised clustering based on prognostic BCSC genes was used to determine BC molecular subtypes. Core genes of BC subtypes identified by non-negative matrix factorization algorithm (NMF) were screened using weighted gene co-expression network analysis (WGCNA). A risk model based on prognostic BCSC genes was constructed using machine learning as well as LASSO regression and multiva...

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A breast cancer classification and immune landscape analysis based on cancer stem-cell-related risk panel

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