SOX8 acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tang, Hailin;Chen, Bo;Liu, Peng;Xie, Xinhua;He, Rongfang;...

通讯作者：

Xiao, Xiangsheng;Xie, Xiaoming

作者机构：

[Xiao, Xiangsheng; Tang, Hailin; Xie, Xinhua; Xiao, XS; Xie, XM; Xie, Xiaoming; Liu, Peng; Zhang, Lijuan; Huang, Xiaojia] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr,Dept Breast Oncol, Guangzhou, Guangdong, Peoples R China.

[Chen, Bo] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Canc Ctr, Dept Breast Canc, Guangzhou, Guangdong, Peoples R China.

[He, Rongfang] Univ South China, Affiliated Hosp 1, Dept Pathol, Hengyang, Hunan, Peoples R China.

通讯机构：

[Xiao, XS; Xie, XM] S

Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr,Dept Breast Oncol, Guangzhou, Guangdong, Peoples R China.

语种：

英文

关键词：

SOX8;ZEB1;cancer stem cells;triple-negative breast cancer

期刊：

CARCINOGENESIS

ISSN：

0143-3334

年：

2019

卷：

期：

页码：

1278-1287

DOI：

10.1093/carcin/bgz034

基金类别：

National Natural Science Foundation of China [81772961 to H.T.; 81672598 to X.X. (Xiaoming Xie)].

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The molecular mechanisms underlying triple-negative breast cancer (TNBC) pathology are not fully understood. Here, we reviewed the SOX8 transcript level in 24 types of cancer and normal tissues and the SOX8 expression pattern in breast cancer from the TCGA and METABRIC data sets and found that SOX8 was highly expressed in TNBC. We investigated the effect of SOX8 on tumorigenicity, migration and apoptosis in TNBC cell lines and xenografts models. We identified SOX8 as a functional oncogene that involved in the maintenance of stem-like capacities in TNBC cells. Through a promoter truncation expe...

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SOX8 acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer

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