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Targeting signal pathways triggered by cyclic peptides in cancer: Current trends and future challenges

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成果类型:
期刊论文
作者:
Yang, Yiyuan;Mao, Hui;Chen, Linxi*;Li, Lanfang*
通讯作者:
Chen, Linxi;Li, Lanfang
作者机构:
[Mao, Hui; Yang, Yiyuan; Li, Lanfang; Chen, Linxi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
通讯机构:
[Chen, Linxi; Li, Lanfang] I
Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, 421001, China. Electronic address:
语种:
英文
关键词:
*Cancer;*Clinic trials;*Cyclic peptide;*Molecular mechanism
期刊:
Archives of Biochemistry and Biophysics
ISSN:
0003-9861
年:
2021
卷:
701
页码:
108776
基金类别:
This work was supported by the grants from the National Natural Science Foundation of China (Grant numbers: 81670265 and 81970431 ), the Hunan Provincial Natural Science Foundation of China (Grant numbers: 2020JJ4079 ) and Innovation Platform Open Foundation of Education Department of Hunan province (Grant numbers: 18K073 ), and Postgraduate Scientific Research Innovation Project of Hunan Province (Grant numbers: CX20200952 ).
机构署名:
本校为第一机构
院系归属:
药学与生物科学学院
摘要:
Cancer is a global health issue that origins thousands of deaths annually worldwide. Cyclic peptides are polypeptide chains which are formed by cyclic sequence of amide bonds between proteinogenic or non-proteinogenic amino acids. Numerous evidences indicate that cyclic peptides are implicated with the occurrence and development of cancer. This review presents the current knowledge about the role of cyclic peptides in cancer, such as liver cancer, colorectal cancer, ovarian cancer, breast cancer as well as prostate cancer. Specifically, the pre...

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