Downregulation of Annexin A1 is correlated with radioresistance in nasopharyngeal carcinoma

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Lifang;Liao, Li;Wan, Yanping;Cheng, Ailan;Li, Meixiang;...

通讯作者：

Zeng, Guqing

作者机构：

[Wan, Yanping; Liao, Li; Zeng, Guqing; Tan, Xing; Chen, Sihan; Huang, Lifang] Univ South China, Sch Nursing, Inst Nursing Res, 28 Changsheng Rd West, Hengyang 421001, Hunan, Peoples R China.

[Cheng, Ailan; Li, Meixiang] Univ South China, Sch Med, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.

[Li, Maoyu] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Zeng, Guqing] U

Univ South China, Sch Nursing, Inst Nursing Res, 28 Changsheng Rd West, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Annexin A1;ionizing radiation;nasopharyngeal carcinoma;radioresistance

期刊：

ONCOLOGY LETTERS

ISSN：

1792-1074

年：

2016

卷：

期：

页码：

5229-5234

DOI：

10.3892/ol.2016.5324

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272959, 81470130, 81072198, 81072199]; Postgraduate Research Project of the University of South China [2015XCX41]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

护理学院

摘要：

Radiotherapy is the primary treatment for nasopharyngeal carcinoma (NPC), but radioresistance often remains an obstacle to successful treatment. In our previous study, it was demonstrated that Annexin A1 (ANXA1) was involved in the p53-mediated radioresponse in NPC cells, which suggested that it may be associated with radioresistance in NPC; however, the role of ANXA1 in NPC radioresistance is unknown. In the present study, CNE2 cells were stably transfected with pLKO.1-ANXA1-small hairpin (sh)RNAs to investigate the effects of ANXA1 on the rad...

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Downregulation of Annexin A1 is correlated with radioresistance in nasopharyngeal carcinoma

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