期刊论文

Jiang, B.

中文

中国普通外科杂志

1005-6947

2022

31

5

631-639

10.7659/j.issn.1005-6947.2022.05.008

湖南省科技厅临床医疗技术创新引导项目（2020SK51705）； 湖南省卫计委科研计划基金资助项目（B20180058）；

本校为第一机构

背景与目的:乳腺癌是全球女性发病率最高的恶性肿瘤,化疗是乳腺癌最重要的治疗方式之一,最近的研究表明,化疗可能通过增强肿瘤微环境中的抗肿瘤免疫力来发挥抗肿瘤效应。因此,本研究通过生物信息学分析明确乳腺癌患者新辅助化疗(NAC)前后肿瘤相关巨噬细胞(TAMs)及相关基因的变化,评估NAC对乳腺癌患者免疫影响。方法:GEO数据库输入“Breast Cancer”,“TAMs”,“Chemotherapy”进行检索,选择人乳腺癌组织的GSE134600数据集进行分析。通过R包(limma函数)筛选乳腺癌患者NAC前后组织样本中差异表达基因(DEGs)。对所有DEGs进行GO功能富集和KEGG通路分析。通过Cytoscape软件对DEGs进行蛋白互作网络可视...

Background and Aims: Breast cancer is the most prevalent malignancy in women worldwide, and chemotherapy is one of the most important treatment modalities for breast cancer. Recent studies have shown that chemotherapy may exert anti-tumor effects by enhancing anti-tumor immunity in the tumor microenvironment. Therefore, this study was conducted to identify the changes in tumor-associated macrophages (TAMs) and relevant genes before and after neoadjuvant chemotherapy (NAC) in breast cancer patients by bioinformatics analysis and to evaluate the ...