The present study was supported by the Natural Science Foundation of china (grant no. 81970389) and the Natural Science Foundation of Hunan Province china (grant nos. 2019JJ50531 and 2020JJ4541).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
The present study aimed to explore the role and mechanisms of proprotein convertase subtilisin/kexin type 9 (PcSK9) in the oxidized low-density lipoprotein (oxLdL)-induced pyroptosis of vascular endothelial cells. For this purpose, human umbilical vein endothelial cells (HUVEcs) were incubated with oxLdL (100 µg/ml) for 24 h to induce pyroptosis, which was detected using PI/hoechst33342 double staining. The expression of pyroptosis-associated mole- cules was measured by western blot analysis and RT-qPcR. Reactive oxygen species (ROS) and membr...