Cholesterol transport system: An integrated cholesterol transport model involved in atherosclerosis

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成果类型：

期刊论文

作者：

Yu, Xiao-Hua;Zhang, Da-Wei;Zheng, Xi-Long;Tang, Chao-Ke*

通讯作者：

Tang, Chao-Ke

作者机构：

[Tang, Chao-Ke; Yu, Xiao-Hua] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Expt Ctr, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.

[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta,Cumming Sch Med, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

[Tang, Chao-Ke] Univ South China, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Chao-Ke] U

Univ South China, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Cholesterol transport system;Atherosclerosis;High-density lipoprotein

期刊：

Progress in Lipid Research

ISSN：

0163-7827

年：

2019

卷：

页码：

65-91

DOI：

10.1016/j.plipres.2018.12.002

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770461]; Hunan Provincial Innovation Foundation for Postgraduate [CX2018B532]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is removed by the reverse cholesterol transport (RCT) pathway, representing a major antiatherogenic mechanism. In addition to the RCT, other pathways are required for maintaining the whole-body cholesterol homeostasis. Thus, we propose a working model of integrated cholesterol transport, termed the cholesterol transport system (CTS), to describe body cholesterol metabolism. The novel model not only involves the classical...

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Cholesterol transport system: An integrated cholesterol transport model involved in atherosclerosis

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