Integrated omics study delineates the dynamics of lipid droplets in Rhodococcus opacus PD630

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成果类型：

期刊论文

作者：

Chen, Yong;Ding, Yunfeng;Yang, Li;Yu, Jinhai;Liu, Guiming;...

通讯作者：

Yu, Jun

作者机构：

[Yang, Fuquan; Huo, Chaoxing; Zhang, Peng; Zhang, Huina; Yang, Li; Ding, Yunfeng; Xie, Zhensheng; Zhang, Shuyan; Xu, Shimeng; Liu, Pingsheng; Chen, Yong; Zhang, Congyan; Wang, Yang; Na, Huimin; Yu, Jinhai] Chinese Acad Sci, Inst Biophys, Natl Lab Macromol, Beijing 100101, Peoples R China.

[Chen, Yong; Zhang, Michael Q.; Li, Yanda] Tsinghua Univ, TNLIST, Ctr Synthet & Syst Biol, Dept Automat,MOE Key Lab Bioinformat, Beijing 100084, Peoples R China.

[Chen, Yong; Zhang, Michael Q.; Li, Yanda] Tsinghua Univ, TNLIST, Ctr Synthet & Syst Biol, Dept Automat,Bioinformat Div, Beijing 100084, Peoples R China.

[Huo, Chaoxing; Zhang, Peng; Yang, Li; Song, Lai; Xu, Shimeng; Zhang, Congyan; Wang, Yang; Zhang, Yue; Na, Huimin; Yu, Jinhai] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

[Liu, Guiming; Huo, Linhe; Song, Lai; Wang, Xumin; Wang, Guoliang; Yu, Jun; Zhang, Hangxiao; Yu, Dan; Fan, Zhonghua; Zhang, Yue] Chinese Acad Sci, Beijing Inst Genom, Key Lab Genome Sci & Informat, Beijing 100101, Peoples R China.

通讯机构：

[Yu, Jun] C

Chinese Acad Sci, Beijing Inst Genom, Key Lab Genome Sci & Informat, Beijing 100101, Peoples R China.

语种：

英文

期刊：

Nucleic Acids Research

ISSN：

0305-1048

年：

2014

卷：

期：

页码：

1052-1064

DOI：

10.1093/nar/gkt932

基金类别：

Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2009CB919000, 2011CBA00906, 2012CB316500, 2012DFG32160]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30971431, 31000365, 61273228, 31100068, 91019016]; Grants-in-Aid for Scientific ResearchMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [24390045] Funding Source: KAKEN

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Rhodococcus opacus strain PD630 (R. opacus PD630), is an oleaginous bacterium, and also is one of few prokaryotic organisms that contain lipid droplets (LDs). LD is an important organelle for lipid storage but also intercellular communication regarding energy metabolism, and yet is a poorly understood cellular organelle. To understand the dynamics of LD using a simple model organism, we conducted a series of comprehensive omics studies of R. opacus PD630 including complete genome, transcriptome and proteome analysis. The genome of R. opacus PD630 encodes 8947 genes that are significantly enric...

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Integrated omics study delineates the dynamics of lipid droplets in Rhodococcus opacus PD630

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