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Design, synthesis and broad-spectrum Bcr-Abl inhibitory activity of novel thiazolamide-benzamide derivatives

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成果类型:
期刊论文
作者:
Liu, Juan;Huang, Honglin;Deng, Xiangping;Xiong, Runde;Cao, Xuan;...
通讯作者:
Peng, Junmei
作者机构:
[Xu, Shiyu; Deng, Xiangping; Liu, Juan; Huang, Honglin; Tang, Guotao; Wu, Xin; Peng, Junmei; Xiong, Runde; Cao, Xuan] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang, Peoples R China.
通讯机构:
[Peng, Junmei] U
Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang, Peoples R China.
语种:
英文
期刊:
RSC Advances
ISSN:
2046-2069
年:
2019
卷:
9
期:
4
页码:
2092-2101
基金类别:
Youth Innovative Talents Training Program Cooperative Innovation Center for Molecular Target New Drug Study [0223-0002-0002000-47]; Hengyang Science and Technology Bureau Project [2015KJ18]; University of South China Doctoral Start-up Fund [2013XQD20]; Graduate Student Science Foundation of University of South China, China [2018492]
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Bcr-Abl plays an important role in the pathogenesis and development of chronic myeloid leukemia (CML). But Bcr-Abl is prone to mutation, so it increases the difficulty of clinical treatment. Therefore, it is crucial to design a new class of broad-spectrum Bcr-Abl inhibitors. Herein, forty novel thiazolamide-benzamide derivatives were synthesized and evaluated their broad-spectrum Bcr-Abl inhibitory activities. The newly synthesized compounds were characterized by using spectrum data ( 1 H NMR, APCI-MS and IR) and elemental analysis. The protein...

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