Validation ESM1 Related to Ovarian Cancer and the Biological Function and Prognostic Significance

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成果类型：

期刊论文

作者：

Li, Yu-kun;Zeng, Tian;Guan, Yang;Liu, Jue;Liao, Nian-chun;...

作者机构：

[Li, Yu-kun; Zou, Juan; Zeng, Tian; Zhang, Qun-feng] Cent South Univ, Xiangya Hosp Zhuzhou, Zhuzhou Cent Hosp, Dept Assisted Reprod Ctr, Zhuzhou, Hunan, Peoples R China.

[Li, Yu-kun; Zou, Juan; Zeng, Tian] Univ South China, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang, Hunan, Peoples R China.

[Guan, Yang] Jiangxi Univ Chinese Med, Sch Pharm, Nanchang, Jiangxi, Peoples R China.

[Liu, Jue; Chen, Ke-xin; Wang, Meng-jie; Liao, Nian-chun; Zhang, Qun-feng] Univ South China, Affiliated Hosp 2, Dept Obstet & Gynecol, Hengyang, Hunan, Peoples R China.

[Luo, Xian-yu] Med Coll, Hunan Polytech Environm & Biol, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

Akt/mTOR pathway;Bioinformatic analysis;ESM1;Ovarian cancer;Prognostic marker

期刊：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES

ISSN：

1449-2288

年：

2023

卷：

期：

页码：

258-280

DOI：

10.7150/ijbs.66839

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Background: Ovarian cancer (OC), a serious gynecological malignant disease, remains an enormous challenge in early diagnosis and medical treatment. Based on the GEO and TCGA databases in R language, endothelial cell-specific molecule 1 (ESM1) was confirmed separately with the bioinformatic analysis tool. ESM1 has been demonstrated to be upregulated in multiple cancer types, but the oncogenic mechanism by which ESM1 promotes OC is still largely unknown. Methods: In this study, we used WGCNA and random survival forest variable screening to filter out ESM1 in OC differentially expressed genes (DE...

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Validation ESM1 Related to Ovarian Cancer and the Biological Function and Prognostic Significance

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