期刊论文

Zheng, Xing

英文

LETTERS IN DRUG DESIGN & DISCOVERY

1570-1808

2020

17

9

1084-1101

10.2174/1570180817999200420115456

This work is supported by Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (2018-10), the general project of the University of South China (18C0438), Hunan Graduate Science and Technology Innovation Projects (CX2018B585), the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (0223-0007-000004), the Undergraduate Research Learning and Innovative Experiment Project, University of South China (2019-100, 2018XJXZ188, 2018XJXZ350, 2018XJXZ194, 2018XJXZ351), the Guiding Project of Hengyang Science and Technology Department (S2018F9031015299), Program for Innovative Talent Team of Hengyang (2017-1), the Key Project of Hengyang Science and Technology Department (2017KJ166) for financial support.

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Background: Oleanolic Acid (OA) is a ubiquitous product of triterpenoid compounds. Due to its inexpensive availability, unique bioactivities, pharmacological effects and non-toxic properties, OA has attracted tremendous interest in the field of drug design and synthesis. Further-more, many OA derivatives have been developed for ameliorating the poor water solubility and bio-availability. Objective: Over the past few decades, various modifications of the OA framework structure have led to the observation of enhancement in bioactivity. Herein, we...