期刊论文

Zheng, Xing

英文

LETTERS IN DRUG DESIGN & DISCOVERY

1570-1808

2020

17

9

1084-1101

10.2174/1570180817999200420115456

Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences [2018-10]; University of South China [18C0438]; Hunan Graduate Science and Technology Innovation Projects [CX2018B585]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [0223-0007-000004]; Undergraduate Research Learning and Innovative Experiment Project, University of South China [2019-100, 2018XJXZ188, 2018XJXZ350, 2018XJXZ194, 2018XJXZ351]; Guiding Project of Hengyang Science and Technology Department [S2018F9031015299]; Program for Innovative Talent Team of Hengyang [2017-1]; Key Project of Hengyang Science and Technology Department [2017KJ166]

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Background: Oleanolic Acid (OA) is a ubiquitous product of triterpenoid compounds. Due to its inexpensive availability, unique bioactivities, pharmacological effects and non-toxic properties, OA has attracted tremendous interest in the field of drug design and synthesis. Furthermore, many OA derivatives have been developed for ameliorating the poor water solubility and bioavailability. Objective: Over the past few decades, various modifications of the OA framework structure have led to the observation of enhancement in bioactivity. Herein, we focused on the synthesis and medicinal performance ...