TAB182 regulates glycolytic metabolism by controlling LDHA transcription to impact tumor radiosensitivity

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成果类型：

期刊论文

作者：

Chen, Shi;Xie, Da-Fei;Li, Saiyu;Luo, Jinhua;Han, Yang;...

通讯作者：

Guan, Hua;Zhou, PK;Huang, RX

作者机构：

[Zhou, Ping-Kun; Gao, Shuaining; Guan, Hua; Chen, Shi] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Luo, Jinhua; Zhou, Ping-Kun; Gao, Shuaining; Guo, Hejiang; Han, Yang; Xie, Da-Fei; Huang, Xin; Guan, Hua; Chen, Shi; Li, Saiyu] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

[Li, Saiyu] Hebei Univ, Sch Life Sci, Baoding 071002, Hebei, Peoples R China.

[Luo, Jinhua; Huang, RX; Huang, Ruixue] Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Guan, H; Zhou, PK ] U

[Huang, RX ] C

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.

语种：

英文

期刊：

CELL DEATH & DISEASE

ISSN：

2041-4889

年：

2024

卷：

期：

页码：

209

DOI：

10.1038/s41419-024-06588-8

基金类别：

National Natural Science Foundation of China [32171238, 82173466, 82230108]

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

Metabolic reprogramming, a hallmark of cancer, is closely associated with tumor development and progression. Changes in glycolysis play a crucial role in conferring radiation resistance to tumor cells. How radiation changes the glycolysis status of cancer cells is still unclear. Here we revealed the role of TAB182 in regulating glycolysis and lactate production in cellular response to ionizing radiation. Irradiation can significantly stimulate the production of TAB182 protein, and inhibiting TAB182 increases cellular radiosensitivity. Proteomic analysis indicated that TAB182 influences several...

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TAB182 regulates glycolytic metabolism by controlling LDHA transcription to impact tumor radiosensitivity

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