Neuroprotective Roles of Apelin-13 in Neurological Diseases

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成果类型：

期刊论文

作者：

Zhang, Yang;Jiang, Weiwei;Sun, Wenjie;Guo, Weiming;Xia, Beibei;...

通讯作者：

Teng Wan<&wdkj&>Mei Yuan

作者机构：

[Zhang, Yang; Yuan, Mei; Sun, Wenjie] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Neurol, Hengyang, Hunan, Peoples R China.

[Wan, Teng] Shenzhen Univ, Huazhong Univ Sci & Technol, Union Shenzhen Hosp, Dept Neurol,Affiliated Hosp 6,Hlth Sci Ctr, Shenzhen 518060, Peoples R China.

[Guo, Weiming] Shenzhen Univ, Huazhong Univ Sci & Technol, Union Shenzhen Hosp, Dept Sports Med,Affiliated Hosp 6,Hlth Sci Ctr, Shenzhen 518060, Peoples R China.

[Jiang, Weiwei; Xia, Beibei; Wan, Teng; Shen, Xiangru; Fu, Mingyuan] Univ South China, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Teng Wan; Mei Yuan] D

Department of Neurology, Huazhong University of Science and Technology Union Shenzhen Hospital, The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China<&wdkj&>Hengyang Medical College, University of South China, Hengyang, China<&wdkj&>Department of Neurology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China

语种：

英文

关键词：

Apelin-13;Neurological diseases;Neuroinflammation;Apoptosis;Neuroprotection

期刊：

Neurochemical Research

ISSN：

0364-3190

年：

2023

卷：

期：

页码：

1648-1662

DOI：

10.1007/s11064-023-03869-0

基金类别：

This study was funded by Key Project of Hunan provincial science and technology innovation (NO. 2020SK1012), Program of Hunan Health Commission (NO.202203072849) and the Natural Science Foundation of Hunan Province (No. 2022JJ30523).

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Apelin is a natural ligand for the G protein-coupled receptor APJ, and the apelin/APJ system is widely distributed in vivo. Among the apelin family, apelin-13 is the major apelin isoform in the central nervous system and cardiovascular system, and is involved in the regulation of various physiopathological mechanisms such as apoptosis, neuroinflammation, angiogenesis, and oxidative stress. Apelin is currently being extensively studied in the nervous system, and apelin-13 has been shown to be associated with the onset and progression of a variety of neurological disorders, including stroke, neu...

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Neuroprotective Roles of Apelin-13 in Neurological Diseases

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