Exogenous Hydrogen Sulfide Regulates Mycoplasma pneumoniae Lipid-Associated Membrane Proteins to Induce Expression of Heme Oxygenase-1 and Proinflammatory Cytokines

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu, Xinnian;Zeng, Wuwei;You, Xiaoxing;Ding, Weiyan;Liu, Peng;...

通讯作者：

Zhu, Cuiming

作者机构：

[Chen, Liesong; Zhu, Cuiming; Liu, Peng; Hu, Xinnian; Zeng, Wuwei; You, Xiaoxing; Ding, Weiyan; Zeng, Yanhua] Univ South China, Inst Pathogen Biol, Hengyang Med Coll,Hunan Prov Cooperat Innovat Ctr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang, Peoples R China.

[Hu, Xinnian] Qingyuan Maternal & Child Hlth Hosp, Qingyuan 511500, Peoples R China.

通讯机构：

[Zhu, Cuiming] U

Univ South China, Inst Pathogen Biol, Hengyang Med Coll,Hunan Prov Cooperat Innovat Ctr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang, Peoples R China.

语种：

英文

关键词：

mycoplasma pneumoniae;hydrogen sulfide (H2S);lipid-associated membrane proteins (LAMPs);proinflammatory cytokines;Heme oxygenase-1(HO-1)

期刊：

Inflammation

ISSN：

0360-3997

年：

2020

卷：

期：

页码：

847-856

DOI：

10.1007/s10753-019-01170-3

基金类别：

This work was supported by the National Natural Science Foundation of China (No. 81441065, No. 31970177); Natural Science Foundation of Hunan Province, China (Grant No. 2019JJ40253); Key Fund Project of Hunan Provincial Department of Education (Grant No. 18A234); and Scientific Research Foundation for the Returned Overseas Chinese Scholars, University of South China (Grant No. 2017XQD25).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

This study was designed to investigate the effect of exogenous hydrogen sulfide (H2S) on the secretion of Heme oxygenase (HO-1) and proinflammatory cytokines in human mononuclear cell line THP-1 stimulated by lipid-associated membrane proteins (LAMPs) prepared from Mycoplasma pneumoniae (M. pneumoniae) and explore its regulatory mechanism. Cultured cells were stimulated with M. pneumoniae LAMPs after pretreatment with H2S to analyze the production of proinflammatory cytokines and HO-1 by enzyme-linked immunosorbent assay (ELISA) and Western blo...

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Exogenous Hydrogen Sulfide Regulates Mycoplasma pneumoniae Lipid-Associated Membrane Proteins to Induce Expression of Heme Oxygenase-1 and Proinflammatory Cytokines

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