期刊论文

Zhao, Yubao

英文

Vaccine

0264-410X

2015

33

17

2066-2072

10.1016/j.vaccine.2015.02.045

Beijing Natural Science FoundationBeijing Natural Science Foundation [7142104]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [20906095, 11405199, 81402861]; Science and Technology Service Network Initiative Project of Chinese Academy of Sciences [KFJ-EW-STS-027, KFJ-EW-STS-098]

本校为第一且通讯机构

Meningococcal disease is a fatal illness of sudden onset caused by Neisseria meningitides. Meningococcal capsular polysaccharide (CPS) is a major virulence factor that generally does not induce immunological memory. Conjugation with a carrier protein can significantly increase the immunogenicity of CPS and induce immunological memory. However, it is highly desired to optimize the CPS-specific immunogenicity of the conjugate vaccine. Although adjuvant has been widely used to improve the immunogenicity of antigens, co-administration and conjugation of adjuvant with the conjugate vaccine has rare...