pH regulators and their inhibitors in tumor microenvironment

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liao, Senyi;Wu, Guang;Xie, Zhizhong;Lei, Xiaoyong;Yang, Xiaoyan;...

通讯作者：

Tang, GT;Wang, Z;Deng, XP

作者机构：

[Yang, Xiaoyan; Xie, Zhizhong; Lei, Xiaoyong; Tang, Guotao; Liao, Senyi] Univ South China, Inst Pharm & Pharmacol, Hengyang Med Sch, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang 421001, Hunan, Peoples R China.

[Wang, Zhe; Wang, Z; Wu, Guang] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

[Deng, Xiangping; Deng, XP] Univ South China, Hengyang Med Sch, Dept Pharm, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Huang, Sheng] Jiuzhitang Co Ltd, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Wang, Z ; Deng, XP ; Tang, GT ] U

Univ South China, Inst Pharm & Pharmacol, Hengyang Med Sch, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, Dept Pharm, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Carbonic anhydrase IX;Monocarboxylate transportors;Na(+)/H(+) exchanger 1;Structure-activity relationship;Tumor microenvironment;pH regulators

期刊：

European Journal of Medicinal Chemistry

ISSN：

0223-5234

年：

2024

卷：

267

页码：

116170

DOI：

10.1016/j.ejmech.2024.116170

基金类别：

CRediT authorship contribution statement Senyi Liao: Writing – original draft. Guang Wu: Writing – original draft. Zhizhong Xie: Writing – review & editing. Xiaoyong Lei: Writing – review & editing. Xiaoyan Yang: Writing – review & editing. Sheng Huang: acquisition, Conceptualization. Xiangping Deng: Writing – review & editing. Zhe Wang: Writing – review & editing. Guotao Tang: Writing – review & editing.

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

As an important characteristic of tumor, acidic tumor microenvironment (TME) is closely related to immune escape, invasion, migration and drug resistance of tumor. The acidity of the TME mainly comes from the acidic products produced by the high level of tumor metabolism, such as lactic acid and carbon dioxide. pH regulators such as monocarboxylate transporters (MCTs), carbonic anhydrase IX (CA IX), and Na+/H+ exchange 1 (NHE1) expel protons directly or indirectly from the tumor to maintain the pH balance of tumor cells and create an acidic TME. We review the functions of several pH regulators...

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pH regulators and their inhibitors in tumor microenvironment

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