LINCS gene expression signature analysis revealed bosutinib as a radiosensitizer of breast cancer cells by targeting eIF4G1

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成果类型：

期刊论文

作者：

Hu, Sai;Xie, Dafei*;Zhou, Pingkun;Liu, Xiaodan;Yin, Xiaoyao;...

通讯作者：

Xie, Dafei;Guan, Hua

作者机构：

[Huang, Bo; Zhou, Pingkun; Hu, Sai] Univ South China, Inst Environm Med & Radiat Hyg, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.

[Guan, Hua; Xie, Dafei; Xie, DF; Zhou, Pingkun; Hu, Sai; Liu, Xiaodan] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, 27 Taiping Rd, Beijing 100850, Peoples R China.

[Yin, Xiaoyao] Natl Univ Def Technol, Coll Comp, Changsha 410073, Hunan, Peoples R China.

通讯机构：

[Xie, DF; Guan, H] B

Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, 27 Taiping Rd, Beijing 100850, Peoples R China.

语种：

英文

关键词：

bosutinib;radiosensitization;LINCS;enrichment score;drug reposition

期刊：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ISSN：

1107-3756

年：

2021

卷：

期：

DOI：

10.3892/ijmm.2021.4905

基金类别：

National Key Basic Research Program (973 Program) of MOST, China [2015CB910601]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [11705283, 81530085, 31870847]; Young Elite Scientists Sponsorship Program of CAST [CSTQT2017003]

机构署名：

本校为第一机构

院系归属：

公共卫生学院

摘要：

Radioresistance is the predominant cause for radiotherapy failure and disease progression, resulting in increased breast cancer‑associated mortality. Using gene expression signature analysis of the Library of Integrated Network‑Based Cellular Signatures (LINCS) and Gene Expression Omnibus (GEO), the aim of the present study was to systematically identify potential candidate radiosensitizers from known drugs. The similarity of integrated gene expression signatures between irradiated eukaryotic translation initiation factor 4γ1(eIF4G1)‑silenc...

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LINCS gene expression signature analysis revealed bosutinib as a radiosensitizer of breast cancer cells by targeting eIF4G1

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