Nanoparticle-induced excessive mitophagy combined with immune checkpoint blockade for enhanced cancer immunotherapy

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成果类型：

期刊论文

作者：

Cao, Yuan;Xu, Rui;Fang, Junyue;Zhao, Zixuan;Wu, Guo;...

通讯作者：

Lu, Yanan;Xu, XD;Lu, YN

作者机构：

[Xu, Rui; Zhao, Zixuan; Xu, Xiaoding; Fang, Junyue; Zhang, Yuxuan; Lu, Yanan; Cao, Yuan; Wu, Guo] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Med Res Ctr, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou 510120, Peoples R China.

[Xu, Rui; Xu, Xiaoding; Fang, Junyue; Zhang, Yuxuan; Cao, Yuan; Wu, Guo] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou Key Lab Med Nanomat, Guangzhou 510120, Peoples R China.

[Lu, Yanan] Sun Yet Sen Univ, Sun Yat Sen Mem Hosp, Dept Anesthesiol, Guangzhou 510120, Peoples R China.

[Li, Rong; Zhao, Zixuan; Xu, Xiaoding] Univ South China, Affiliated Hosp 2, Hunan Prov Key Clin Lab Basic & Clin Pharmacol Res, Hengyang Med Sch,Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Lu, YN ; Xu, XD ; Lu, YN] S

Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Med Res Ctr, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou 510120, Peoples R China.

Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou Key Lab Med Nanomat, Guangzhou 510120, Peoples R China.

Sun Yet Sen Univ, Sun Yat Sen Mem Hosp, Dept Anesthesiol, Guangzhou 510120, Peoples R China.

Univ South China, Affiliated Hosp 2, Hunan Prov Key Clin Lab Basic & Clin Pharmacol Res, Hengyang Med Sch,Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Cancer immunotherapy;Mitophagy;Nanoplatform;RNA interfering (RNAi);Tumor microenvironment (TME)

期刊：

Acta Biomaterialia

ISSN：

1742-7061

年：

2025

卷：

204

页码：

534-546

DOI：

10.1016/j.actbio.2025.08.001

基金类别：

National Natural Science Foundation of China [82173392, 82403670]; Guangdong Basic and Applied Basic Research Foundation [2024B1515040006, 2025A1515012481]; Guangdong S T Program [2023B1111030006]; Guangzhou Science and Technology Bureau [2024A03J0846]; Natural Science Foundation of Hunan Province [2023JJ50149]; Foundation of Hunan Provincial Key Laboratory [2023TP1014]; The "Three million for Three Years" Project of the High-level Talent Special Funding Scheme of Sun Yat-Sen Memorial Hospital

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Tumor microenvironment (TME) is the major obstacle in cancer immunotherapy due to its adverse effects on tumor-infiltrating immune cells. Emerging evidences have revealed that mitophagy plays an important role in regulating cell fate and immune microenvironment. Targeted regulation of mitophagy could be a promising strategy for enhanced cancer immunotherapy, which however remains unexploited due to the absence of robust therapeutic platform. We herein developed a mitophagy-induced RNA interfering (RNAi) nanoplatform composed of a hydrophilic polyethylene glycol (PEG) shell and an endosomal pH-...

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Nanoparticle-induced excessive mitophagy combined with immune checkpoint blockade for enhanced cancer immunotherapy

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