In pH 4.0 Britton-Robinson (BR) buffer solution, lomefloxacin could react with copper (Ⅱ) to form chelate cations, which further bind with eosin B to form association. This resulted in the obvious enhancement of resonance Rayleigh scatter/ng (RRS). The maximum RRS wavelength situated at 380 nm. The intensities of RRS at 380 nm are proportional to the concentrations of lomefloxacin in the ranges of 8.99× 10^-8 - 3.00 × 10^-6 tool/L, the detection limit (3Sb/k) is 2.69× 10^-8 mol/L. Based on this, a new method was developed for the determination of FLQS ...