期刊论文

中文

应用化工

1671-3206

2012

41

2

227-228,236

10.16581/j.cnki.issn1671-3206.2012.02.009

(04SK3053-3):湖南省科技厅资助课题

本校为第一机构

1-(3-氟苯)-2-溴-1-丙酮在非质子极性溶剂中经胺化、环合反应,最后酸化,得到3-甲基-5-苯基-2-(3-氟基苯基)吗啉盐酸盐,总收率为70.6%。目标化合物结构经IR、~1H NMR、MS测试技术确证。参照Porsolt法,使用小鼠强迫游泳药理实验模型,对所合成的化合物进行抗实验性抑郁药理活性研究。结果显示,此化合物具有良好的抗抑郁活性,值得进一步研究。

3-Methyl-5-phenyl-2-（3-fluorophenyl）morpholine hydrochloride was synthesized from 2-bromo-1-（3-fluorophenyl）-1-propanone via aminnation and cyclization in nonproton polar solvent,at last acidified by divergent synthetic method,with yield of 70.6%.Its structure was confirmed by IR and 1H NMR.Their antidepressant activities were tested with mice forced swimming test.The compound is worth to the f...