期刊论文

中文

应用化工

1671-3206

2011

40

6

1011-1014

10.16581/j.cnki.issn1671-3206.2011.06.027

湖南省大学生研究性学习与创新性实验计划基金项目（湘教通〔2009〕154号）；

本校为第一机构

用β-环糊精（-βCD）键合硅胶合成了一种新型的β-环糊精/S iO2手性固定相,用红外对其进行了结构鉴定。将该手性固定相用于薄层色谱分离萘普生外消旋体,考察多种溶剂对萘普生外消旋体的展开效果,结果表明,乙酸乙酯∶氯仿（体积比）=1∶4为展开剂时,合成的手性固定相对DL-萘普生的分离度为1.45,具有很好的拆分DL-萘普生的能力。

A new kind of β-CD/SiO2 chiral stationary phase was synthesized bonded on the silica gel and characterized by IR spectrometry.It was used as chiral stationary phase of thin-layer chromatography to separate racemic naproxen.The separation of DL-naproxen by several different mobile phase was studied,and the best volume ratio of ethyl acetate to chloroform was 1∶4.The results showed that it had an excellent separate capability and th...