Proteomic characteristics of PM2.5 -induced differentially expressed proteins in human renal tubular epithelial cells

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成果类型：

期刊论文

作者：

Li, Boru;Qin, Shuangjian;Cai, Ying;Zheng, Kai;Wang, Bingyu;...

通讯作者：

Zeng, M.

作者机构：

[Qin, Shuangjian; Xiao, Fang; Zeng, Ming; Li, Boru] Cent South Univ, Xiangya Sch Publ Hlth, Dept Hlth Toxicol, Changsha 410078, Hunan, Peoples R China.

[Xu, Xinyun; Cai, Ying; Qin, Shuangjian; Li, Runbing; Wang, Bingyu; Li, Boru; Zheng, Kai; Huang, Haiyan] Shenzhen Ctr Dis Control & Prevent, Inst Environm & Hlth, Shenzhen 518055, Guangdong, Peoples R China.

[Cai, Ying; Li, Runbing; Wang, Bingyu; Zheng, Kai] Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zeng, M.] D

Department of Health Toxicology, China

语种：

英文

关键词：

Bioinformatics;Differentially expressed proteins;Human renal epithelial cells;PM2.5;Proteomics

期刊：

Environmental Toxicology and Pharmacology

ISSN：

1382-6689

年：

2021

卷：

页码：

103658

DOI：

10.1016/j.etap.2021.103658

基金类别：

Shenzhen Science and Technology Innovation Committee [JCYJ20190807102205480, 20190801152345759, JCYJ20170413101713324]; Guangdong Provincial Natural Science FoundationNational Natural Science Foundation of Guangdong Province [2019A1515011080]; Sanming Project of Medicine in Shenzhen [SZSM201611068]; Shenzhen Key Medical Discipline Construction Fund [SZXK067]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Human renal epithelial (HK-2) cells were treated with PM2.5 (50 μg/mL) from Shenzhen and Taiyuan, proteomics and bioinformatics were used to screen the differentially expressed proteins (DEPs). A total of 577 DEPs were screened after HK-2 cells exposed to Shenzhen PM2.5, of which 426 were up-regulated and 151 were down-regulated. A total of 1250 DEPs were screened in HK-2 cells after exposure to Taiyuan PM2.5, of which 488 were up-regulated and 185 were down-regulated. The top 10 proteins with the highest number of nodes were screened using th...

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Proteomic characteristics of PM2.5 -induced differentially expressed proteins in human renal tubular epithelial cells

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