Proteomic characteristics and identification of PM2.5-induced differentially expressed proteins in hepatocytes and c-Myc silenced hepatocytes

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成果类型：

期刊论文

作者：

Qin, Shuangjian;Li, Boru;Li, Runbing;Cai, Ying;Zheng, Kai;...

通讯作者：

Xiao, Fang;Zeng, Ming;Xu, Xinyun

作者机构：

[Qin, Shuangjian; Xiao, Fang; Zeng, Ming; Xiao, F; Li, Boru] Cent South Univ, Xiangya Sch Publ Hlth, Changsha 410078, Hunan, Peoples R China.

[Xu, Xinyun; Cai, Ying; Qin, Shuangjian; Li, Runbing; Li, Boru; Zheng, Kai; Huang, Haiyan] Shenzhen Ctr Dis Control & Prevent, Inst Environm & Hlth, Shenzhen 518055, Guangdong, Peoples R China.

[Cai, Ying; Li, Runbing; Zheng, Kai] Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Xiao, F; Zeng, M] C

[Xu, Xinyun] S

Cent South Univ, Xiangya Sch Publ Hlth, Changsha 410078, Hunan, Peoples R China.

Shenzhen Ctr Dis Control & Prevent, Inst Environm & Hlth, Shenzhen 518055, Guangdong, Peoples R China.

语种：

英文

关键词：

PM2.5;L02 hepatocytes;c-Myc gene silence;Proteomics;Bioinformatics

期刊：

Ecotoxicology and Environmental Safety

ISSN：

0147-6513

年：

2021

卷：

209

页码：

111838

DOI：

10.1016/j.ecoenv.2020.111838

基金类别：

Shenzhen Science and Technology Innovation Committee, China [JCYJ20190807102205480, JCYJ20170413101713324, 20190801152345759]; Natural Science Foundation of Guangdong Province, ChinaNational Natural Science Foundation of Guangdong Province [2019A1515011080]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Proteomics and bioinformatics were applied to explore PM(2.5)-induced differentially expressed proteins (DEPs) in hepatocytes (L02 cells) and c-Myc-silenced hepatocytes. L02 cells and c-Myc-silenced hepatocytes were treated with PM(2.5) for 24h. Fifty-two DEPs were screened in L02 hepatocytes, of which 28 were upregulated and 24 were downregulated. Forty-one DEPs were screened in the c-Myc-silenced hepatocytes, of which 31 were upregulated and 10 were downregulated. GO analysis showed that DEPs in L02 cells were mainly concentrated in the cytosol and were involved in biological processes such ...

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Proteomic characteristics and identification of PM2.5-induced differentially expressed proteins in hepatocytes and c-Myc silenced hepatocytes

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