Involvement of TRPV1 in the expression and release of calcitonin gene-related peptide induced by rutaecarpine

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yang, Yongmei;Chen, Qingquan;Jia, Sujie;He, Limei;Wang, Aiping;...

通讯作者：

Li, Xiaohui

作者机构：

[He, Limei; Chen, Qingquan; Li, Xiaohui; Yang, Yongmei; Li, Yuanjian] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, 110 Xiang Ya Rd, Changsha 410078, Hunan, Peoples R China.

[Wang, Aiping; Yang, Yongmei] Univ South China, Sch Med, Dept Anat, Hengyang 421001, Hunan, Peoples R China.

[Jia, Sujie] Cent S Univ, Third Xiangya Hosp, Dept Pharm, Changsha 410013, Hunan, Peoples R China.

[Li, Dai] Cent S Univ, Natl Inst Drug Clin Trial, Xiangya Hosp, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Li, Xiaohui] C

Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, 110 Xiang Ya Rd, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

calcitonin gene-related peptide;hypertension;rutaecarpine;transient receptor potential cation channel subfamily V member 1

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2018

卷：

期：

页码：

5168-5174

DOI：

10.3892/mmr.2018.8494

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81200035, 81273513]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The traditional Chinese herb Wu-Chu-Yu has been used to treat hypertension for hundreds of years. A previous study indicated that rutaecarpine was the effective component of Wu-Chu-Yu, which lowered blood pressure by elevating the expression level of calcitonin gene-related peptide (CGRP). The present-study was performed to investigate the role of transient receptor potential cation channel subfamily V member 1 (TRPV1) in CGRP expression and release induced by rutaecarpine. Dorsal root ganglia (DRG) obtained from Sprague-Dawley rats were cultur...

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Involvement of TRPV1 in the expression and release of calcitonin gene-related peptide induced by rutaecarpine

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