SLC39A8-mediated zinc dyshomeostasis potentiates kidney disease

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成果类型：

期刊论文

作者：

Cai, Zhaoxian;Wu, Xiaotian;Wang, Tianyi;Song, Zijun;Ni, Pu;...

通讯作者：

Wang, FD;Min, JX

作者机构：

[Su, Yunxing; Ni, Pu; Wu, Xiaotian; Cai, Zhaoxian; Wang, Fudi; Lin, Yangjun] Zhejiang Univ, Affiliated Hosp 2, State Key Lab Expt Hematol, Sch Publ Hlth,Sch Med, Hangzhou 310058, Peoples R China.

[Min, Junxia; Xie, Enjun; Cai, Zhaoxian; Song, Zijun; Sun, Shumin] Zhejiang Univ, Affiliated Hosp 1, Inst Translat Med, Sch Med, Hangzhou 310058, Peoples R China.

[Cai, Zhaoxian; Wang, Fudi; Wang, Tianyi; Zhong, Meijuan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Sch Publ Hlth,Basic Med Sci, Hengyang 421001, Peoples R China.

通讯机构：

[Wang, FD ; Min, JX ] Z

Zhejiang Univ, Affiliated Hosp 2, State Key Lab Expt Hematol, Sch Publ Hlth,Sch Med, Hangzhou 310058, Peoples R China.

Zhejiang Univ, Affiliated Hosp 1, Inst Translat Med, Sch Med, Hangzhou 310058, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Sch Publ Hlth,Basic Med Sci, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

SLC39A8;SLC39A8 A391T;kidney disease;rs13107325;zinc homeostasis

期刊：

Proceedings of the National Academy of Sciences of the United States of America

ISSN：

0027-8424

年：

2025

卷：

122

期：

页码：

e2426352122

DOI：

10.1073/pnas.2426352122

基金类别：

MOST | National Natural Science Foundation of China (NSFC) [82471593, 32330047, 32100941] Funding Source: Medline; China Postdoctoral Science Foundation (China Postdoctoral Foundation Project) [2020M681898] Funding Source: Medline

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

While numerous genetic risk loci are linked to kidney disease, a unifying therapeutic target for diverse renal pathologies remains elusive. Here, through large-cohort polymorphic locus screening, we identify the SLC39A8 A391T variant (rs13107325) as a shared modifier of multiple kidney diseases. Functional characterization using Slc39a8 A391T knock-in mice and kidney-specific Slc39a8 knockout mice reveals that loss of SLC39A8 function reduces renal zinc accumulation, thereby mitigating susceptibility to kidney injury and disease progression. Mechanistically, we demonstrate that perturbed zinc ...

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SLC39A8-mediated zinc dyshomeostasis potentiates kidney disease

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